Merrifield Resin HL (100–200 mesh): High-Loading Solid Support for Reliable Synthesis
Introduction
Merrifield Resin HL (High Loading), 100–200 mesh, is a chloromethylated polystyrene-based resin used extensively in solid-phase synthesis. Originally introduced by Nobel Laureate R. Bruce Merrifield in 1963, this resin remains a cornerstone of peptide chemistry and solid-phase organic synthesis (SPOS) due to its robust chemical stability, ease of functionalization, and high reactivity.
The 100–200 mesh particle size offers an optimal balance between surface area and flow properties, making it suitable for both manual and automated synthesizers.
Product Highlights
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Matrix: Cross-linked polystyrene (typically 1% DVB)
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Loading: High Loading (HL), typically 1.0–1.4 mmol/g
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Particle Size: 100–200 mesh (approx. 75–150 µm)
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Appearance: White to off-white spherical beads
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Swelling Behavior: Swells well in DCM, THF, DMF, and other organic solvents
Applications
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Solid-Phase Peptide Synthesis (SPPS)
Merrifield resin is traditionally used in Boc-based SPPS protocols, where the chloromethyl group anchors the first amino acid via ester linkage. It is also adaptable for Fmoc strategies with appropriate linkers. -
Solid-Phase Organic Synthesis (SPOS)
Widely used for the synthesis of small molecules, heterocycles, and libraries in medicinal chemistry and combinatorial chemistry. -
Reagent and Catalyst Immobilization
The chloromethyl groups can be readily transformed into other functional moieties, making it a versatile platform for attaching ligands, catalysts, or scavengers.
Advantages
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High Loading Capacity: Supports higher yields per gram of resin, particularly useful in parallel or scale-up synthesis.
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Proven Utility: One of the most extensively studied and validated solid supports in synthetic chemistry.
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Chemical Stability: Compatible with a broad range of solvents, reagents, and reaction conditions.
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Adaptability: Can be functionalized with a variety of linkers or groups to suit diverse synthetic goals.
Storage and Handling
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Store in a sealed container in a cool, dry place.
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Protect from prolonged exposure to light and moisture.
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Before use, swell the resin in an appropriate solvent for 30 minutes to ensure optimal reactivity.
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Avoid strong oxidizers and prolonged exposure to strong acids or bases.
Conclusion
Merrifield Resin HL (100–200 mesh) is a reliable and flexible solid-phase synthesis resin, offering high loading and robust performance for a variety of synthetic applications. Whether used in peptide synthesis, organic library generation, or immobilization of catalysts, it provides a solid foundation for reproducible and efficient chemistry.
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